Projects

 

 

We study the essential roles of microtubules in the neuron and how they are regulated during development. We also study how microtubule-based mechanisms go awry during injury and disease of the nervous system. The broad goals are to expand the body of knowledge on these important topics, and to use the gathered knowledge to develop therapies for treating patients with nerve injuries or disease. Graduate Students and Postdoctoral Fellows are specifically involved in the following projects:

 

PROJECT 1: Developmental/Cellular Neuroscience : Role of molecular motor proteins in the transport and organization of microtubules underlying:
- Axon growth and retraction
- Axon branching

- Axon navigation/pathfinding

- Dendrite development
- Neuronal migration

 

 

 

 

 

 

 

 

PROJECT 2: Developmental/Cellular Neuroscience Role of microtubule-severing proteins in the transport and organization of microtubules underlying:
- Axon growth and retraction
- Axon branching
- Axon navigation/pathfinding

- Dendrite development
- Neuronal migration

 

 

 

 

 

 

 

PROJECT 3: Neurodegenerative Disease: Role of microtubule-related proteins and microtubule-based mechanisms in neurodegenerative diseases, with emphasis on:
- Hereditary Spastic Paraplegia

- Alzheimers disease

 

 

 

 

 

 

 

 

 

 

 

PROJECT 4: Injury and repair: Role of microtubule-related proteins and microtubule based mechanisms in the response to injury of damaged nerves, with emphasis on:
- Peripheral nerve injury
- Spinal cord injury
- Traumatic brain injury