Substance Abuse

Current projects on substance abuse focus on the involvement of hypocretin systems in the regulation of psychostimulant abuse and its effects on dopamine and norepinephrine signaling.  The laboratory employs a variety of techniques including fast scan cyclic voltammetry, microdialysis, multi-electrode single unit electrophysiology, EEG/EMG recordings and a series of behavioral assays.

 

Hypocretin receptor 1 antagonists reduce cocaine self-administration

   

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Mice lacking hypocretin peptides display reduced dopamine responses to cocaine High affinity dopamine uptake blockers produced rapid onset uptake inhibition