Hypocretins

Since 1998 we have been investigating the neurobiology of the hypocretin (HCRT) system, with a particular emphasis on its involvement in the regulation of sleep/wake processes, stress and motivated behaviors.

We are currently involved in a series of studies examining the importance of HCRT signaling in the regulation of reinforcment processes involving both natural and drug rewards.

 

HCRT peptides exert rapid wake-promoting effects

   
Blockade of HCRT 1 receptors in the ventral tegmental area reduces dopamine responses to cocaine Mice lacking HCRT peptides display reduced dopamine responses to cocaine