Norepinephrine and Dopamine

The laboratory has a longstanding interest in the involvement of monoaminergic signaling in the regulation of arousal-related processes. In particular we are interested in the extent to which these neurotransmitters influence motivated behavior by modulating levels of arousal.

We are using fast scan cyclic voltammetry to examine changes in dopamine and norepinephrine signaling across the sleep/wake cycle and in response to specific behavioral states.

 

Spontaneous DA release events observed in a resting mouse