Research Articles

Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, España RA. Addict Biol. Epub ahead of print(2016)

The GLP-1 agonist exendin-4 attenuates self-administration of sweetened fat on fixed and progressive ratio schedules of reinforcement in rats. Bernosky-Smith KA, Stanger DB, Trujillo AJ, Mitchell LR, España RA, Bass CE. Pharmacol Biochem Behav 142:48-55.(2016)

Dopamine uptake dynamics are preserved under isoflurane anesthesia. Brodnik ZD, España RA Neurosci Lett, 606:129-134(2015)

Reduced dopamine and glutamate neurotransmission in the nucleus accumbens of quinpirole-sensitized rats hints at inhibitory D2 autoreceptor function. Escobar AP, Cornejo FA, Olivares-Costa M, González M, Fuentealba JA, Gysling K, España RA, Andrés ME J Neurochem 134:1081-90 (2015)

Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep. Brodnik ZD, Bernstein DL, Prince CD, España RA Behav Brain Res, 291:377-84 (2015)

Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1. Prince CD, Rau AR, Yorgason JT, España RA ACS Chem Neurosci, 291:377-84 (2015)

Dopamine transporters govern diurnal variation in extracellular dopamine tone. Ferris MJ, España RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR Proc Natl Acad Sci 111(26):E2751-9 (2014)

Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, España RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ Eur J Neurosci, 40(1):2255-63 (2014)

Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals Ferris MJ, Calipari ES, Melchior JR, Roberts DC, España RA, Jones SR Eur J Neurosci, 37(6):1022-31 (2013)

Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats Yorgason JT, España RA, Konstantopoulos JK, Weiner JL, Jones SR Eur J Neurosci, 38(4):2628-36 (2013)

Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward Oleson EB, Ferris MJ, España RA, Harp J, Jones SR Eur J Pharmacol, 2683(1-3):161-5 (2012)

Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection Yorgason, JT, Jones SR, España, RA Neuroscience, 182:125-32 (2011)

Demon voltammetry and analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures Yorgason, JT, España, RA, Jones SR Journal of Neuroscience Methods, 2:158-164 (2011)

Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self- administration España RA, Melchior JR, Roberts DCS, Jones SR Psychopharmacology (Berl), 214(2):415-426 (2011)

Hypocretin/Orexin regulates cocaine self-administration via actions on the mesolimbic dopamine system España, RA, Oleson, E, Locke, JL Roberts, DCS, Jones, SR European Journal of Neuroscience, 31:336-348 (2010)

Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717 Hampson RE, España RA, Rogers GA, Porrino LJ, Deadwyler SA Psychopharmacology 202(1-3):355-69 (2009)

Coping behavior causes asymmetric changes in neuronal activation in the prefrontal cortex and amygdala Stalnaker TA, España RA, Berridge CW Synapse,63(1):82-5 (2009)

Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery España, RA, Roberts DCS, Jones, SR Neuroscience, 155:250-257, 2008

Running promotes wakefulness and increases cataplexy in orexin knockout mice España RA, McCormack SL, Mochizuki T, Scammell TE Sleep. 2007 Nov;30(11):1417-25

Organization of noradrenergic efferents to arousal-related basal forebrain structures España, RA, and Berridge, CW Journal of Comparative Neurology, 496 (5):668-683 (2006)

Afferents to the orexin neurons of the rat brain Yoshida K, McCormack S, España RA, Crocker A, Scammell TE J Comp Neurol. 2006 494(5):845-61

Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structures España, RA, Reis, KM, Valentino, RJ, and Berridge, CW J Comp Neurol, 481 (2):160-178 (2005)

Concomitant loss of dynorphin, NARP, and orexin in narcolepsy Crocker A, España RA, Papadopoulou M, Saper CB, Faraco J, Sakurai T, Honda M, Mignot E, Scammell TE Neurology, 65(8):1184-8 (2005)

Diurnal levels of Fos immunoreactivity are elevated within hypocretin neurons in lactating mice España RA, Berridge CW, Gammie SC Peptides, 25(11):1927-34 (2004)

Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration España RA, Valentino RJ, Berridge CW Neuroscience, 121(1):201-1 (2003)

Additive wake-promoting actions of medial basal forebrain noradrenergic alpha1- and beta-receptor stimulation Berridge CW, Isaac SO, España RA Behav Neurosci, 117(2):350-9 (2003)

Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures Lin SH, Arai AC, España RA, Berridge CW, Leslie FM, Huguenard JR, Vergnes M, Civelli O Neuroscience, 114(1):229-38 (2002)

Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin España RA, Plahn S, Berridge CW Brain Res, 943(2):224-36 (2002)

Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action España, RA, Baldo, BA, Kelley, AE, and Berridge, CW Neuroscience, 106 (4): 699-715 (2001)

Synergistic sedative effects of noradrenergic alpha(1)- and beta-receptor blockade on forebrain electroencephalographic and behavioral indices Berridge CW, España RANeuroscience, 99(3):495-505 (2000)