Selected Articles

Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, España RA. Addict Biol. Epub ahead of print(2016)

Dopamine uptake dynamics are preserved under isoflurane anesthesia. Brodnik ZD, España RA Neurosci Lett, 606:129-134 (2015)

Reduced dopamine and glutamate neurotransmission in the nucleus accumbens of quinpirole-sensitized rats hints at inhibitory D2 autoreceptor function. Escobar AP, Cornejo FA, Olivares-Costa M, González M, Fuentealba JA, Gysling K, España RA, Andrés ME J Neurochem 134:1081-90 (2015)

Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1. Prince CD, Rau AR, Yorgason JT, España RA ACS Chem Neurosci, 291:377-84 (2015)

Dopamine transporters govern diurnal variation in extracellular dopamine tone. Ferris MJ, España RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR Proc Natl Acad Sci 111(26):E2751-9 (2014)

Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, España RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ Eur J Neurosci, 40(1):2255-63 (2014)

Presynaptic dopamine modulation by stimulant self-administration Espana RA, Jones SR Front Biosci, 5:261-76 (2013)

Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms Calipari ES, España RA. Front Behav Neurosci, 6:54. (2012)

Noradrenergic modulation of wakefulness/arousal Berridge CW, Schmeichel BE, España RA Sleep Med Rev, 16(2):187-97 (2012)

Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection Yorgason, JT, Jones SR, España, RA Neuroscience, 182:125-32 (2011)

Demon voltammetry and analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures Yorgason, JT, España, RA, Jones SR Journal of Neuroscience Methods, 2:158-164 (2011)

Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self- administration España RA, Melchior JR, Roberts DCS, Jones SR Psychopharmacology (Berl), 214(2):415-426 (2011)

Hypocretin/Orexin regulates cocaine self-administration via actions on the mesolimbic dopamine system España, RA, Oleson, E, Locke, JL Roberts, DCS, Jones, SR European Journal of Neuroscience, 31:336-348 (2010)

Hypocretin/orexin in arousal and stress Berridge CW, España RA, Vittoz NM Brain Research, 1314:91-102 (2010)

Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery España, RA, Roberts DCS, Jones, SR Neuroscience, 155:250-257, 2008

Running promotes wakefulness and increases cataplexy in orexin knockout mice España RA, McCormack SL, Mochizuki T, Scammell TE Sleep. 2007 Nov;30(11):1417-25

Organization of noradrenergic efferents to arousal-related basal forebrain structures España, RA, and Berridge, CW Journal of Comparative Neurology, 496 (5):668-683 (2006)

Afferents to the orexin neurons of the rat brain Yoshida K, McCormack S, España RA, Crocker A, Scammell TE J Comp Neurol. 2006 494(5):845-61

Organization of hypocretin/orexin efferents to locus coeruleus and basal forebrain arousal-related structures España, RA, Reis, KM, Valentino, RJ, and Berridge, CW J Comp Neurol, 481 (2):160-178 (2005)

Hypocretins: waking, arousal, or action? Berridge CW, España RA Neuron. 46(5):696-8 2005)

Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration España RA, Valentino RJ, Berridge CW Neuroscience, 121(1):201-1 (2003)

Additive wake-promoting actions of medial basal forebrain noradrenergic alpha1- and beta-receptor stimulation Berridge CW, Isaac SO, España RA Behav Neurosci, 117(2):350-9 (2003)

Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action España, RA, Baldo, BA, Kelley, AE, and Berridge, CW Neuroscience, 106 (4): 699-715 (2001)