Gene Therapy, Modified Fibroblasts and Matrices
Hayashi Y, Shumsky JS, Connors T, Otsuka T, Fischer I, Tessler A, Murray M. Immunosuppression with either cyclosporine a or FK506 supports survival of transplanted fibroblasts and promotes growth of host axons into the transplant after spinal cord injury.J Neurotrauma. 2005 Nov;22(11):1267-81. abstract PDF
Mitsui T, Fischer I, Shumsky JS, Murray, M. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder function following spinal contusion injury in rats. Exp Neurol. 2005:194(2):410-31. abstract PDF
Nothias JM, Mitsui T, Shumsky JS, Fischer I, Antonacci MD, Murray M. Combined effects of neurotrophin secreting transplants, exercise, and serotonergic drug challenge improve function in spinal rats. Neurorehabil Neural Repair. 2005 Dec;19(4):296-312. abstract PDF
Tobias CA, Han SS, Shumsky JS, Kim D, Tumolo M, Dhoot NO, Wheatley MA, Fischer I, Tessler A, Murray M. Alginate encapsulated BDNF-producing fibroblast grafts permit recovery of function after spinal cord injury in the absence of immune suppression. J. Neurotrauma 2005:22:138-156. abstract PDF
Bakshi A, Fisher O, Dagci T, Himes BT, Fischer I, Lowman A. Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury. J Neurosurgery Spine 2004:3:322-329. abstract
Dhoot NO, Tobias CA, Fischer I, Wheatley MA. Peptide-modified alginate surfaces as a growth permissive substrate for neurite outgrowth. J. Biomedical Materials Research Part A 2004:71:191-200. abstract PDF
Tobias CA, Shumsky JS, Shibata M, Tuszynski MH, Fischer I, Tessler A, Murray M. Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy and provides limited regeneration. Exp Neurol 2003:184:97-113. abstract PDF
Jin Y, Fischer I, Tessler A, Houle JD. Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Exp Neurol. 2002 Sep;177(1):265-75. abstract PDF
Liu Y, Himes BT, Murray M, Tessler A, Fischer I. Grafts of BDNF-producing fibroblasts rescue axotomized rubrospinal neurons and prevent their atrophy. Experimental Neurol. 2002:178:150-164. abstract PDF
Himes BT, Liu Y, Solowska JM, Snyder EY, Fischer I, Tessler A. Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats. J. Neurosci. Res. 2001:65:549-564. abstract PDF
Kim D, Schallert T, Liu Yi. Browarak,T, Nayeri N, Tessler A, Fischer I, Murray, M. Transplantation of genetically modified fibroblasts expressing BDNF in adult rats with a subtotal hemisection improves specific motor and sensory functions. Neurorehabilitation and Neural Repair. 2001:15:141-150 abstract
Tobias CA, Dhoot NO, Wheatley MA, Tessler A, Murray M, Fischer I. Grafting of encapsulated BDNF-producing fibroblasts into inured spinal cord without immune suppression in adult rats. J. Neurotrauma 2001:18:287-301 abstract PDF
Jin Y, Tessler A, Fischer I, Houle JD. Fibroblasts genetically modified to produce BDNF support regrowth of chronically injured serotonergic axons. Neurorehabilitation and Neural Repair 2000:14:311-317. abstract
Tobias CA, Kim D, Fischer I. Improved recombinant retroviral titers utilizing trichostatin A. BioTechniques, 2000:29:884-89 abstract
Liu Y, Kim Y, Himes T, Chow S, Murray M, Tessler A, Fischer I. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons. J. Neuroscience 1999:19:4370-4387 abstract PDF
Liu Y, Himes T, Tryon B, Moul J, Chow SY, Jin H, Murray M, Tessler A, Fischer I. Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses. NeuroReport 1998:9:1075-1079 abstract PDF
Liu Y, Himes T, Moul J, Huang W, Chow S, Tessler A, Fischer I. Application of recombinant adenovirus for in vivo gene delivery to spinal cord. Brain Res. 1997:768:19-29 abstract PDF
