FISCHERLAB DUCOM Spinal Cord Research Center

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Gene Therapy, Modified Fibroblasts and Matrices


Ollivier-Lanvin K, I Fischer, V Tom JD. Houlé and MA. Lemay. Either Brain-Derived Neurotrophic Factor or Neurotrophin-3 Only Neurotrophin-Producing Grafts Promote Locomotor Recovery in Untrained Spinalized Cats. 2014. Neurorehabilitation and Neural Repair The online version of this article can be found at: DOI: 10.1177/1545968314532834 published online 6 May 2014. PMID: 24803493

Haas C and Fischer I. 2013. Human astrocytes derived from glial restricted progenitors support regeneration of the injured spinal cord. Journal of Neurotrauma. Jun 15;30(12):1035-52. doi: 10.1089/neu.2013.2915. Epub 2013 Jun 12. PMID:  23635322

Saglam A, Perets A, Canver AC, Li H, Kollins K, Cohen G, Fischer I, Lazarovici P, and Peter I. Lelkes PI. 2012. Angioneural Crosstalk in Scaffolds with Oriented Microchannels for Regenerative Spinal Cord Injury Repair. J Mol Neurosci. Feb;49(2):334-46. doi: 10.1007/s12031-012-9863-9. Epub 2012 Aug 10.

Francis NL, Shanbhag MS, Fischer I, and Wheatley MA. 2011. Influence of alginate cross-linking method on neurite response to microencapsulated neurotrophin-producing fibroblasts. J. Microencapsulation. 28(5):353-62. PMID: 21736520

Conova L, Vernengo J, Jin Y, Himes BT, Neuhuber B, Fischer I, Lowman A. 2011 A pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cord. J Neurosurg Spine 15:594-604. PMID:21888482

Comolli, N. K., B. Neuhuber, I. Fischer, and A. M. Lowman. 2008. In vitro analysis of a novel injectable polymeric scaffold for spinal cord repair. Acta Biomater. 5(4):1046-1055.  [Epub ahead of print] PMCID: PMC2844850

Boyce VS, Tumolo M, Fischer I, Murray M, Lemay MA. 2007. Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats. J Neurophysiol 98:1988-96.

            deLeon RD. Could neurotrophins replace treadmill training as locomotor therapy following spinal cord injury? Commentary. J Neurophysiol (same issue).

Tobias CA, Han SSW, Shumsky JS, Kim D, Tumolo M, Dhoot NO, Wheatley MA, Fischer I, Tessler A, Murray M. (2005). Alginate encapsulated BDNF-producing fibroblast grafts permit recovery of function after spinal cord injury in the absence of immune suppression. J. Neurotrauma 22:138-156.

Nothias, J-M, Mitsui T, Shumsky JS, Fischer I, Antonacci MD, Murray M. (2005). Combined effects of neurotrophin secreting transplants, exercise and serotonergic drug challenge improve function in spinal rats. Neurorehab Neur Rep. 19:296-312.

Hayashi Y, Shumsky JS, Connors T, Otsuka T, Fischer I, Tessler A, Murray M. (2005). Immunosuppression with either cyclosporine A or FK 506 promotes repair processes after spinal cord injury. J. Neurotrauma 22:1267-1281.

Dhoot NO, Tobias CA, Fischer I, Wheatley MA.  (2004). Peptide-modified alginate surfaces as a growth permissive substrate for neurite outgrowth.  J. Biomed Materials Res 71:191-200.

Tobias CA, Shumsky JS, Shibata M, Tuszynski MH, Fischer I, Tessler A, Murray M. (2003). Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy and provides limited regeneration. Exp Neurol 184:97-113.

Emery DL, Royo NC, Fischer I, Saatman KE, McIntosh TK. (2003). Plasticity following injury to the adult central nervous system: Is recapitulation of a developmental state worth promoting? J Neurotrauma 20:1271-1292.

Murray M, Kim D, Liu Y, Tobias C, Tessler A, Fischer I. (2002). Transplantation of genetically modified cells  contributes to repair and recovery from spinal injury. Brain Res. Reviews. 40:292-300.

Liu Y, Himes BT, Murray M, Tessler A, Fischer I.  2002.  Grafts of BDNF-producing fibroblasts that promote regeneration of axotomized rubrospinal neurons also rescue most neurons from retrograde death and prevent their atrophy. Experimental Neurol. 178:150-164.

Jin Y, Fischer I, Tessler A, Houle JD. (2002). Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Exp Neurol 177:265-275.

Tobias CA, Dhoot NO, Wheatley MA, Tessler A, Murray M, Fischer I (2001). Grafting of encapsulated BDNF-producing fibroblasts into inured spinal cord without immune suppression in adult rats. J. Neurotrauma 18:287-301

Jin Y, Tessler A, Fischer I, Houle JD (2001) Fibroblasts genetically modified to produce BDNF support regrowth of chronically injured serotonergic axons. Neurorehab. Neural Repair 14: 319-330

Himes BT, Liu Y, Solowska, JM, Snyder EY, Fischer I. and Tessler A. (2001). Transplants of cells genetically modified to express NT-3 keep alive axotomized Clarke’s nucleus neurons after spinal cord hemisection in adult rats. J. Neurosci. Res. 65:549-564.

Kim D, Schallert T, Liu Yi. Browarak,T, Nayeri N, Tessler A, Fischer I, Murray, M. (2001). Transplantation of genetically modified fibroblasts expressing BDNF in adult rats with a subtotal hemisection improves specific motor and sensory functions. Neurorehabilitation and Neural Repair. 15:141-150

Ma D, Himes T, Shea T, and Fischer I (2000). Axonal transport of microtubule associated protein 1B (MAP1B) in sciatic nerve of adult rats: Distinct transport rates for different isoforms. J. Neurosci. 20:2112-2120.

Emery DL, Raghupathi R, Saatman KE, Fischer I, McIntosh TK (2000). Bilateral growth-related protein expression suggests a transient increase in regenerative potential following brain trauma. J. Comp. Neurol., 424(3):521-531

Tobias CA, Kim D, Fischer I (2000). Improved recombinant retroviral titers utilizing trichostatin A BioTechniques, 29:884-89.

Liu Y, Murray M, Tessler A, Fischer I. (2000). Grafting of genetically modified fibroblasts into the injured spinal cord. Prog Br Res 128:309-319.

Liu Y, Himes T, Solowska-Baird, J, Moul J, Chow S, Tessler A, Snyder, E and Fischer (1999) Intraspinal delivery of neurotrophin-3 (NT-3) using stem-like cells genetically modified by recombinant retrovirus. Exp Neurol 158:9-26.

Liu Y, Kim Y, Himes T, Chow S, Murray M, Tessler A, and Fischer I (1999) Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons. J. Neurosci. 19:4370-4387.

Liu Y, Himes T, Moul J, Chow S, Jin H, Murray M, Tessler A, and Fischer I (1998) Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses. NeuroReport 9:1075-1079.

Liu Y, Himes T, Moul J, Huang W, Chow S, Tessler A, Fischer I (1997) Application of recombinant adenovirus for in vivo gene delivery to spinal cord.  Brain Res. 768:19-29.

Review and Books

Blesch A, Fischer I, Tuszynski MH. (2012) Handbook of Clinical Neurol, Chapter 37: Gene Therapy, Neurotrophic Factors and Spinal Cord Regeneration.

Murray M, Fischer I. (2001). Transplantation and gene therapy: Combined approaches for repair of spinal cord injury. Neuroscientist 7:28-41.

Fischer I, Liu Y (2000) Gene Therapy strategies in CNS axon regeneration. In Nerve Regeneration. Ingoglia N and Murray M (eds). pp. 563-602, Marcel and Dekker.

Liu Y, Murray M, Tessler A, Fischer I (2000). Grafting of genetically modified fibroblasts into the injured spinal cord. In Seil FJ, Ed, Progress in Brain Research, Neural Plasticity and Regeneration. 128:309-322, Elsevier Science.





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