FISCHERLAB DUCOM Spinal Cord Research Center

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Bone Marrow Stromal Cells


Krupka AJ, Fischer I, Lemay MA 2016) Transplants of neurotrophin-producing autologous fibroblasts promote recovery of treadmill stepping in the acute, sub-chronic, and chronic spinal cat (submitted).

Zhukareva, V., M. Obrocka, J. D. Houle, I. Fischer, and B. Neuhuber. 2010. Secretion profile of human bone marrow stromal cells: donor variability and response to inflammatory stimuli. Cytokine. 50(3):317-321. PMID:20185331

Samdani, A. F., C. Paul, R. R. Betz, I. Fischer, B. Neuhuber. 2009. Transplantation of human marrow stromal cells and mono-nuclear bone marrow cells into the injured spinal cord. Spine. 34(24):2605-2612.

Paul, C., A. F. Samdani, R. R. Betz, I. Fischer, B. Neuhuber. 2009. Grafting of bone marrow stromal cells into spinal cord injury: A comparison of delivery methods. Spine 34(4):328-34.

Neuhuber, B., S. A. Swanger, L. Howard, A. Mackay, and I. Fischer. 2008. Effects of plating density and culture time on bone marrow stromal cell characteristics. Exp. Hematol. 36(9):1176-1185.

Neuhuber, B., A. L. Barshinger, C. Paul, J. Shumsky, T. Mitsui, and I. Fischer. 2008. Stem cell delivery by lumbar puncture is a suitable alternative to cell delivery by direct injection. J. Neurosurgery. Spine 9(4):390-399.

Himes BT, Neuhuber B, Coleman C, Kushner R; Swanger SA, Kopen GC, Wagner J, Shumsky JS, Fischer I. (2006) Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord. Neurorehab. Neural Repair 20(2):278-296.

Yoshihara H, Shumsky JS, Neuhuber B, Otsuka T, Fischer I, Murray M. (2006). Combining motor training with transplantation of rat bone marrow stromal cells does not improve repair or recovery in rats with thoracic coontusion injuries.  Brain Res. 1119(1):65-75. PMID:17027672

Bakshi A, Barshinger AL, Swanger SA, Madhavani V, Shumsky JS, Neuhuber B, Fischer I. (2006). Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: A novel method for minimally invasive cell transplantation. J.Neurotrauma, 23:55-65.

Swanger SA, Neuhuber B, Himes BT, Bakshi A, Fischer I. (2005). Analysis of allogeneic and syngeneic bone marrow stromal cell graft survival in the spinal cord. Cell Transplant 14:775-786. PMID 16454352 PMC Journal-in process

Neuhuber B, Himes BT, Shumsky JS, Gallo G, Fischer I. (2005). Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations. Brain Res 1035:73-85.

Neuhuber B, Gallo G, Howard L, Kostura L, Mackay A, Fischer I. (2004). Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: Disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype. J Neurosci. Res.  77:192-204.

Deng W, Obrocka M, Fischer I, Prockop D (2001) In vitro differentiation of human stromal cells into neuron-like cells by conditions that increase intracellular cyclic AMP. Biol. Biophy. Res Comm. 282:148-152.

Review and Books

Neuhuber B, and I. Fischer. (2010). Intrathecal delivery of stem cells to the spinal cord. In: K. K. Jain (ed.), Drug delivery to the central nervous system, Series: Neuromethods 45, Humana Press – Springer. Chapter 10:219-232.

Murray M, Fischer I. (2001). Transplantation and gene therapy: Combined approaches for repair of spinal cord injury. Neuroscientist 7:28-41.

Fischer I (2000). Candidate cells for transplantation into the injured CNS. In Seil FJ, Ed,  Progress in Brain Research, Neural Plasticity and Regeneration. 128:253-258, Elsevier Science.





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