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Ying Jin, Ph.D.
Research Assistant Professor, Dept. Neurobiology and Anatomy, Drexel University College of Medicine
Email: yjin@drexelmed.edu

Axonal regeneration and functional recovery after spinal cord injury

Biography

Ying Jin received her Ph.D. degree from the University of Hong Kong and her postdoctoral training from University of Arkansas for Medical Sciences and University of Kentucky. She is now a research assistant professor in the Department of Neurobiology and Anatomy at Drexel University College of medicine.

Research and Interest

My research is focused on spinal cord injury by using multiple approaches to protect injured spinal cord, reduce scar formation, and promote axonal regeneration and functional recovery. Now I am working on a combination treatment of stem cell transplantation and gene therapy to bridge the lesion cavity, reduce the glial scar, promote and guide axonal growth after spinal cord injury, special in the chronic stage of spinal cord injury.

Selected Publications

Jin Y, Tay D, So K-F, Wu W (2000) Expression of c-Jun in the lateral vestibular nucleus following spinal cord injury and peripheral nerve graft transplantation in adult rats. Journal of Neurocytology, 29 (2): 91-97. PMID: 11068337

Jin Y, Tessler A, Fischer I, Houle JD (2000) Fibroblasts genetically modified to produce BDNF support regrowth of chronically injured serotonergic axons. Journal of Neurorehabilitation and Neural Repair. 14: 311-317. PMID: 11402881

Houle JD, Jin Y (2001) Chronically injured supraspinal neurons exhibit only modest axonal dieback in response to cervical hemisection lesion. Experimental Neurology 169 (1): 208-217. PMID: 11312573

Springer JE, Nottingham SA, McEwen ML, Azbill RD, Jin Y (2001) Caspase-3 apoptotic signaling following injury to the central nervous system. Clinical Chemistry Laboratory Medicine 39(4):299-307. PMID: 11388652

Jin Y, Fischer I, Tessler A, Houle JD (2002).Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Experimental Neurology 177(1): 265-275. PMID: 12429228

Jin Y, McEwen ML, Nottingham SA, Maragos WF, Dragichevic NB, Sullivan PG, Springer JE (2004) The mitochondrial uncoupling agent 2,4-Dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increase white matter sparing in the contused spinal cord. Journal of Neurotrauma 21(10): 1396-1404. PMID: 15672630

Jin Y, McEwen ML, Ghandour MS, Springer JE (2004) Overexpression of XIAP inhibits apoptotic cell death in an oligodendroglial cell line. Cellular and Molecular Neurobiology 24(6): 853-863. PMID: 15672685

Cai J, Ziemba KS, Smith GM, Jin Y (2007) Evaluation of cellular organization and axonal regeneration through linear PLA foam implants in acute and chronic spinal cord injury. Journal of Biomedical Materials Research Part A. 83(2):512-520. PMID: 17503492

Ziemba KS, Chaudhry N, Rabchevshy AG, Jin Y, Smith GM (2008) Targeting axon growth from neuronal transplantation in the adult central nervous system along preformed guidance pathways. J. Neurosci. 28, 340-348. PMID: 18184776

Jin Y, Ziemba KS, Smith GM (2008) Axon growth across a lesion site along a preformed guidance pathway in the brain. Exp. Neurol., 210(2):521-30. PMID: 18261727

Jin Y, Zhang C, Ziemba KS, Goldstein GA, Sullivan PG and Smith GM (2011) Directing dopaminergic fiber growth along a preformed molecular pathway from embryonic ventral mesencephalon transplants in the rat brain. J. Neurosci Res., 89(5):619-27. PMID: 21337366

Jin Y, Neuhuber B, Singh A, Bouyer J, Lepore A, Bonner J, Himes T, Campanelli JT, Fischer I (2011) Transplantation of human glial restricted progenitors and derived astrocytes into a contusion model of spinal cord injury. Journal of Neurotrauma. PMID: 21222572

Jin Y. Ketschek A, Jiang ZL, Smith GM, Fischer I (2011) Chondroitinase activity can be transduced by lentiviral vector in vitro and in vivo. J Neurosci Methods (in press).