Michel Lemay, Ph.D.
Adjunct Professor, Dept. Neurobiology and Anatomy, Drexel University College of Medicine
Neural Prosthesis and Spinal Circuitry
Research and Interest
My laboratory is interested in studying and utilizing spinal circuits responsible for movements in neural prosthesis applications. Neural prostheses use electrical activation of a damaged nervous system to restore function to the affected individual. Dr. Giszter's Laboratory demonstrated the modularity of the spinal frog motor output to intraspinal microstimulation, while my laboratory and a number of other groups have shown similar primitives for movement control in the mammalian spinal cord. The laboratory is currently focusing on elucidating the effects of spinal injury on the spinal motor ouput, and the interactions between intraspinal microstimulation, neural transplants promoting regeneration, and sensorimotor training aimed at shaping the regenerating pathways. The tools and techniques used include computer-based modeling of limb biomechanics, kinematic analysis of movement behavior, and in vivo stimulation and recording of force, motion and muscular activation in pre-clinical models.
Michel Lemay, Adjunct Professor of Neurobiology and Anatomy at Drexel University College of Medicine and Professor in the Department of Bioengineering at Temple University, received his Ph.D. in Biomedical Engineering from Case Western Reserve University. Following training as an NIDRR and SCRF post-doctoral fellow at M.I.T. and as a Research Associate at Case Western Reserve, Dr. Lemay joined the faculty at Drexel University College of Medicine in 2001 and the Department of Bioengineering at Temple University in 2013.
“Motoneuronal and muscle synergies involved in cat hindlimb control during fictive and real locomotion: a comparison study"
SN Markin, MA Lemay, BI Prilutsky, and IA Rybak
J Neurophysiology, Vol. 107, pp. 2057-2071, 2012.
“Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord”
JF Bonner, TM Connors, WF Silverman, DP Kowalski, MA Lemay and I Fischer
J Neuroscience, Vol. 31, pp. 4675-4686, 2011.
“Population spatiotemporal dynamics of spinal intermediate zone interneurons during air-stepping in adult spinal cats”
N AuYong, K Ollivier-Lanvin and MA Lemay
J Neurophysiology, Vol. 106, pp. 1943-1953, 2011.
“Electrical stimulation of the sural cutaneous afferent nerve controls the amplitude and onset of the swing phase of locomotion in the spinal cat”
K Ollivier-Lanvin, A Krupka, N AuYong, K Miller, BI Prilutsky and MA Lemay
J Neurophysiology, Vol. 105, pp. 2297-2308, 2011.
“Preferred locomotor phase of activity of lumbar interneurons during air-stepping in sub-chronic spinal cats”
N AuYong, K Ollivier-Lanvin and MA Lemay
J Neurophysiology, Vol. 105, pp. 1011-1022, 2011.
“Afferent control of locomotor CPG: Insights from a simple neuro-mechanical model”
SN Markin, AN Klishko, NA Shevtsova, MA Lemay, BI Prilutsky and IA Rybak
Annals of NY Academy of Science, Vol. 1198, pp. 21-34, 2010.
“Hindlimb endpoint forces predict movement direction evoked with intraspinal microstimulation in cats”
MA Lemay, D Grasse and WM Grill
IEEE Transactions on Neural Systems and Rehabilitation Engineering 2009.
“Modularity of endpoint force patterns evoked using intraspinal microstimulation in treadmill trained and/or neurotrophin treated chronic spinal cats”
VS Boyce, and MA Lemay
J. Neurophysiology, Vol. 101, pp. 1309-1329, 2009.
“Role of biomechanics and muscle activation strategy in the production of endpoint force patterns in the cat hindlimb”
MA Lemay, M Bhowmik-Stoker, GC McConnell and WM Grill
The Journal of Biomechanics, Vol. 40, pp. 3679-3687, 2007.
“Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats”; “Could neurotrophins replace treadmill training as locomotor therapy following spinal cord injury?”
VS Boyce, M Tumolo, I Fischer, M Murray and MA Lemay
J. Neurophysiology, Vol. 98, pp. 1988-96, in same issue. 2007.
“Fibrillation potentials following spinal cord injury: Improvement with neurotrophins and exercise”
AS Burns, VS Boyce, A Tessler and MA Lemay
Muscle and Nerve, Vol. 35, pp. 607-613, 2007.
“Abnormal spontaneous potentials in distal muscles in animal models of spinal cord injury”
AS Burns, MA Lemay and A Tessler
Muscle and Nerve, Vol. 31, pp. 46-51, 2005.
“Modularity of motor output evoked by intraspinal microstimulation in cats”
MA Lemay and WM Grill
J. Neurophysiol., Vol. 91, pp. 502-514, 2004.