Network Model of the Respiratory CPG

          Network model of the respiratory CPG

Collaborators:

Julian F. R. Paton
University of Bristol, Bristol, UK

James S. Schwaber
Thomas Jeffereson University
Philadelphia, PA

Animated schematic of the respiratory CPG model: Active neurons, excitatory synaptic connections and inflated lung are shown red. Inhibitory synaptic connections are shown blue.

Performance of the model with and without PSR feedback (vagotomy).

Disconnection of PSR feedback in the model causes: (i) an increase in duration and amplitude of ramp-I neuron and phrenic discharges reflecting the loss of the Hering-Breuer inspiration-inhibiting reflex (Cohen 1979; Euler 1986; Feldman 1986); and (ii) a decrease in duration of the post-I neuron burst and postinspiratory phase (Richter et al. 1986).

Related Publications:

    Rybak, I. A., Paton, J. F. R., and Schwaber, J. S. (1997) Modeling neural mechanisms for genesis of respiratory rhythm and pattern: I. Models of respiratory neurons. J. Neurophysiol. 77: 1994-2006.
      Rybak, I. A., Paton, J. F. R., and Schwaber, J. S. (1997) Modeling neural mechanisms for genesis of respiratory rhythm and pattern: II. Network models of the central respiratory pattern generator. J. Neurophysiol. 77: 2007-2026.
      Rybak, I. A., Paton, J. F. R., and Schwaber, J. S. (1997) Modeling neural mechanisms for genesis of respiratory rhythm and pattern: III. Comparison of model performances during afferent nerve stimulation. J. Neurophysiol. 77: 2027-2039.