Dorsal Raphe

The brainstem dorsal raphe nucleus (DRN) utilizes multiple neurotransmitter systems in mediating a variety of adaptive and maladaptive behaviors including stress, anxiety, depression, sleep, feeding, pain and nociception.

In this horizontal section from a rat brainstem, neurons releasing serotonin (green) are concentrated along the midline of the raphe, while neurons that synthesize nitric oxide (red) are concentrated in the caudolateral wings