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Wenqian Yu, M.D.
Research Instructor, Dept. Neurobiology and Anatomy, Drexel University College of Medicine
Email: wyu@drexelmed.edu

Regulation of Microtubules in Developing Neurons

Research and Interest

My research in the Baas laboratory has been focused on microtubule transport in the axon, the role of the centrosome in generating axonal microtubules, the regulation of the dendritic microtubule array, the fragmentation of microtubules underlying collateral branch formation, and the role of microtubule severing proteins and molecular motor proteins in regulating key events in the establishment of neuronal polarity.

Selected Publications

Yu, W., V.E. Centonze, F.J. Ahmad, and P.W. Baas. 1993. Microtubule nucleation and release from the neuronal centrosome. J. Cell Biol. 122: 349-359.

Yu, W., and P.W. Baas. 1994. Changes in microtubule number and length during axon differentiation. J. Neurosci. 14: 2818-2829.

Lustig, R.H., P. Hua, W. Yu, F.J. Ahmad, and P.W. Baas. 1994. An in vitro model for the effects of estrogen on neurons employing estrogen receptor-transfected PC12 cells. J. Neurosci. 14: 3945-3957.

Yu, W., F.J. Ahmad, and P.W. Baas. 1994. Microtubule fragmentation and partitioning in the axon during collateral branch formation. J. Neurosci. 14: 5872-5884.

Sharp, D.J., W. Yu, and P.W. Baas. 1995. Transport of dendritic microtubules establishes their nonuniform polarity orientatation. J. Cell Biol. 130: 93-104.

Yu, W., and P.W. Baas. 1995. The growth of the axon is not dependent upon the net assembly of microtubules at its distal tip. J. Neurosci. 15: 6827-6833.

Yu, W., M.J. Schwei, and P.W. Baas. 1996. Microtubule transport and assembly during axon growth. J. Cell Biol. 133: 151-157.

Baas, P.W., and Yu, W., 1996. A composite model for establishing the microtubule arrays of the neuron. Molecular Neurobiology 12: 145-161.

Wang, J., Yu, W., P.W. Baas, and M.M. Black. 1996. Microtubule assembly in growing dendrites. J. Neurosci., 16(19):6065-6078.

W. Yu, D.J. Sharp, R. Kuriyama, P. Mallik, and P.W. Baas. 1997. Inhibition of a mitotic motor compromises the formation of dendrite-like processes from neuroblastoma cells. J. Cell Biol. 136(3): 659-668.

D.J. Sharp, W. Yu, L. Ferhat, R. Kuriyama, D.C. Rueger, and P.W. Baas. 1997. Identification of a Microtubule-associated motor protein essential for dendritic differentiation. J. Cell Biol. 138(4): 833-843.

F. J. Ahmad, W. Yu, F. J. McNally, and P. W. Baas. 1999. An essential role for Katanin in severing microtubules in the neuron. J. Cell Biol. 145(2): 305-315.

W. Yu, C. Sauter, C. Cook, R. Kuriyama, F. J. Kaplan, and P. W. Baas. 2000. Inhibition of a microtubule-associated motor protein induces the loss of dendritic identity. J. Neurosci., 20: 5782-5791.

W. Yu, C. Ling, and P. W. Baas. 2001. Microtubule Reconfiguration during Axogenesis. J. Neurocytol., 30:861-875.

Y. He, W. Yu, and P.W. Baas. 2002. Microtubule Reconfiguration during Axonal Retraction Induced by Nitric Oxide. J. Neurosci., 22(14):5982-5991.

D.W. Buster, D.H. Baird, W. Yu, J.M.S-Baird, M. Chauviere, A. Mazurek, M. Kress, and P.W. Baas. 2003. Expression of the Mitotic Kinesin KIF15 in Postmitotic Neurons: Implications for Neuronal Migration and Development. J. Neurocytol., 32:79-96.

Arzu Karabay, Wenqian Yu, Joanna M. Solowska, Douglas H. Baird, and Peter W. Baas. 2004. Axonal Growth Is Sensitive to the Levels of Katanin, a Protein That Severs Microtubules. J. Neurosci., 24(25): 5778-5788.

He, Y., F. Frances, K.A. Myers, W. Yu, M. Black, and P.W. Baas. 2005. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. J. Cell Biol. 168: 697-703.

Yu, W., J.M. Solowska, L. Qiang, A. Karabay, D. Baird, and P.W. Baas. 2005. Regulation of microtubule severing by katanin subunits during neuronal development. J. Neurosci. 25: 5573-5583.

Qiang L, Yu W, Andreadis A, Luo M, Baas PW. Tau protects microtubules in the axon from severing by katanin. J Neurosci. 2006 Mar 22;26(12):3120-9.

Yu W, Qiang L, Solowska JM, Karabay A, Korulu S, Baas PW. The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches. Mol Biol Cell. 2008 Apr;19(4):1485-98. Epub 2008 Jan 30.

Yu W, Qiang L, Solowska JM, Karabay A, Korulu S, Baas PW. The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches. Mol Biol Cell. 2008 Apr;19(4):1485-98. Epub 2008 Jan 30.